Epithelial-myoepithelial carcinoma of the breast is a rare biphasic tumor composed of intermixed malignant epithelial and\nmyoepithelial components. Myoepithelial cells are known to adopt varied morphologies, including spindle, chondroid, clear cell,\nand rhabdoid morphologies, and can represent a diagnostic challenge when isolated on biopsy. Rhabdomyosarcoma, phyllodes\ntumor, metaplastic carcinoma, and myoepithelial carcinoma are primary breast tumors that all have been shown to exhibit\nrhabdoid features, whether representing true differentiation or morphological mimic. We here report an epithelial-myoepithelial\ncarcinoma of the breast with rhabdoid features in a 76-year-old woman. The rhabdoid-appearing myoepithelial cells are\nnegative for myogenin, consistent with a rhabdoid-like morphology rather than a true rhabdoid differentiation, comparably to\npreviously described myoepithelial carcinoma with rhabdoid features. To our knowledge, this is the first reported case of\nepithelial-myoepithelial carcinoma of the breast with rhabdoid features and thus adds another entity to the differential diagnosis\nof breast lesions with rhabdoid features.
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